Cytoreductive surgery (CRS) is a surgical procedure that aims to reduce the amount of cancer cells in the abdominal cavity for patients with

tumor A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

s that have spread intraabdominally (

peritoneal carcinomatosis Peritoneal carcinomatosis (PC) is intraperitoneal dissemination ( carcinosis) of any form of cancer that does not originate from the peritoneum itself. PC is most commonly seen in abdominopelvic malignancies. Computed tomography (CT) is particu ...

). It is often used to treat ovarian cancer but can also be used for other abdominal malignancies. CRS is often used in combination with

hyperthermic intraperitoneal chemotherapy Intraperitoneal hyperthermic chemoperfusion (HIPEC or IPHC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. In this procedure, warmed anti-cancer medications are infused and circul ...

(HIPEC), for some cancer diagnosis it considerably increases life expectancy and reduces the rate of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

recurrence. Its main developer was

Paul Sugarbaker Paul Hendrick Sugarbaker (born November 28, 1941, in Baltimore) is an American surgeon at the Washington Cancer Institute. He is known for developments in surgical oncology of the abdomen, including cytoreductive surgery followed by hyperthermic i ...

who is known for the development of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy, or HIPEC, a treatment alternately referred to as the Sugarbaker Procedure.

Ovarian cancer

Among patients with stage III

epithelial ovarian cancer Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial or Fallopi ...

, the addition of HIPEC to interval cytoreductive surgery resulted in longer recurrence-free survival and

overall survival Survival rate is a part of survival analysis. It is the proportion of people in a study or treatment group still alive at a given period of time after diagnosis. It is a method of describing prognosis in certain disease conditions, and can be use ...

than surgery alone and did not result in higher rates of

side effects In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...

Colorectal cancer

Among colorectal cancer patients with peritoneal carcinomatosis cytoreductive surgery, with the addition of HIPEC can be used to prolong overall survival in patients.

References

{{reflist Surgery Mesothelioma Cancer